What is the best explanation for the presentation of gout in this individual and explain why the other choices are not consistent with the data or what additional information you may need to decide the root cause?
1. overproduction of purines
2. decreased salvage of purines
3. decreased urinary excretion of uric acid
OPTION 3 - decreased urinary excretion of uric acid
Explanation:
Gout is an extremely painful condition where the joints are inflamed, especially the big toe, caused by a metabolic defect resulting in the accumulation of URIC ACID in the blood and the deposition of urates around the joints.
Additional information:
Uric acids belong to the PURINE group, it occurs in very small amount in the urine of some animals and usually nontoxic.
Options 1 and 2 does not explain gout
the best explanation is 1. overproduction of purines
Explanation:
Purines are nitrogenous base that are broken down to uric acid which is excreted through the kidney as a constituent of urine. Different conditions that lead to an impaired removal of plasma uric acid cause gout. Soda drinks and many soft drinks contain low levels of purines and high level of fructose. Fructose is the only carbohydrate known to increase uric acid levels by increase the rate of degradration and synthesis of purine